ELASPIC home << Job #oncokb << P31751.H355M
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31751.H355M

Detailed results for job #oncokb produced by ELASPIC
P31751, RAC-beta serine/threonine-protein kinase:
H355M
1
481
PH
Pkinase+Pkinase_C
SHANK3, SH3 and multiple ankyrin repeat domains protein 3:
1
1731
S..
PDZ
..
Ank_2
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Model: Wild-type | Mutant | Both
Protein: P31751 | SHANK3 | Cofactors | All
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P31751.H355M

Completed successfully

Protein, domain: P31751 Pkinase+Pkinase_C

Interacting with: SHANK3 Ank_2

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.287, 0.301 Model score: 1.663

ELASPIC ΔΔG: 1.933

ELASPIC2 (EL2) score: 1.490

Mutation run by user.

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Citation

If you use these results, please cite the papers on this page.