ELASPIC home << Job #oncokb << P31749.T195I
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.T195I

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
T195I
1
480
PH
Pkinase+Pkinase_C
CDKN1A, Cyclin-dependent kinase inhibitor 1:
1
164
CDI
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Model: Wild-type | Mutant | Both
Protein: P31749 | CDKN1A | Cofactors | All
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P31749.T195I

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: CDKN1A CDI

PDB templates used: 1jsu_A, 1jsu_C

Seq identity: 0.268, 0.435 Model score: 0.967

ELASPIC ΔΔG: 0.485

ELASPIC2 (EL2) score: 1.457

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.