ELASPIC home << Job #oncokb << P31749.L362R
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.L362R

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
L362R
1
480
PH
Pkinase+Pkinase_C
MAP3K8, Mitogen-activated protein kinase kinase kinase 8:
1
467
Pkinase
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Protein: P31749 | MAP3K8 | Cofactors | All
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P31749.L362R

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: MAP3K8 Pkinase

PDB templates used: 3a60_A, 3a60_B

Seq identity: 0.445, 0.278 Model score: 0.876

ELASPIC ΔΔG: -0.381

ELASPIC2 (EL2) score: 1.756

Mutation run by user.

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Citation

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