ELASPIC home << Job #oncokb << P31749.L321A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P31749.L321A

Detailed results for job #oncokb produced by ELASPIC
P31749, RAC-alpha serine/threonine-protein kinase:
L321A
1
480
PH
Pkinase+Pkinase_C
RHEB, GTP-binding protein Rheb:
1
184
Ras
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P31749.L321A

Completed successfully

Protein, domain: P31749 Pkinase+Pkinase_C

Interacting with: RHEB Ras

PDB templates used: 2v55_C, 2v55_D

Seq identity: 0.372, 0.257 Model score: 0.385

ELASPIC ΔΔG: 2.972

ELASPIC2 (EL2) score: 1.931

Mutation run by user.

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Citation

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