ELASPIC home << Job #oncokb << P23458.K1026E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P23458.K1026E

Detailed results for job #oncokb produced by ELASPIC
P23458, Tyrosine-protein kinase JAK1:
K1026E
1
1154
Pkinase_Tyr
Pkinase_Tyr
KPCZ isoform 3, Isoform 3 of Protein kinase C zeta type:
1
488
C1_1
Pkinase+Pkinase_C
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P23458.K1026E

Completed successfully

Protein, domain: P23458 Pkinase_Tyr

Interacting with: KPCZ isoform 3 Pkinase+Pkinase_C

PDB templates used: 4e4n_A, 4e4n_B

Seq identity: 0.962, 0.242 Model score: 0.036

ELASPIC ΔΔG: 0.059

ELASPIC2 (EL2) score: 1.004

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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