ELASPIC home << Job #oncokb << P22607.N653H
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P22607.N653H

Detailed results for job #oncokb produced by ELASPIC
P22607, Fibroblast growth factor receptor 3:
N653H
1
806
I-set
I-set
Pkinase_Tyr
FGFR3 isoform 4, Isoform 4 of Fibroblast growth factor receptor 3:
1
791
I-set+I-set+ig
Pkinase_Tyr
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P22607.N653H

Completed successfully

Protein, domain: P22607 Pkinase_Tyr

Interacting with: FGFR3 isoform 4 Pkinase_Tyr

PDB templates used: 4j96_B, 4j96_A

Seq identity: 0.859, 0.822 Model score: 0.120

ELASPIC ΔΔG: 3.315

ELASPIC2 (EL2) score: -0.754

Mutation in database: COSMIC.

Download:  PDBwt   | PDBmut

Citation

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