ELASPIC home << Job #oncokb << P21802.K526E
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P21802.K526E

Detailed results for job #oncokb produced by ELASPIC
P21802, Fibroblast growth factor receptor 2:
K526E
1
821
I-set
I-set
Pkinase_Tyr
CDK9 isoform 2, Isoform 2 of Cyclin-dependent kinase 9:
1
489
Pkinase
Select affected interaction:

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P21802.K526E

Completed successfully

Protein, domain: P21802 Pkinase_Tyr

Interacting with: CDK9 isoform 2 Pkinase

PDB templates used: 4j99_B, 4j99_A

Seq identity: 0.970, 0.284 Model score: -0.235

ELASPIC ΔΔG: 0.875

ELASPIC2 (EL2) score: 0.106

Mutation in database: UniProt.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.