ELASPIC home << Job #oncokb << P10398.F351L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P10398.F351L

Detailed results for job #oncokb produced by ELASPIC
P10398, Serine/threonine-protein kinase A-Raf:
F351L
1
606
RBD
C1_1
Pkinase_Tyr
FKBP5, Peptidyl-prolyl cis-trans isomerase FKBP5:
1
457
FKBP_C
FKBP_C
TPR_1
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Protein: P10398 | FKBP5 | Cofactors | All
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P10398.F351L

Completed successfully

Protein, domain: P10398 Pkinase_Tyr

Interacting with: FKBP5 FKBP_C

PDB templates used: 4c02_A, 4c02_B

Seq identity: 0.318, 0.500 Model score: 0.135

ELASPIC ΔΔG: 1.024

ELASPIC2 (EL2) score: 0.787

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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