ELASPIC home << Job #oncokb << P04637.H179Q
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P04637.H179Q

Detailed results for job #oncokb produced by ELASPIC
P04637, Cellular tumor antigen p53:
H179Q
1
393
P53_TAD
P53+P53_tetramer
TP53BP2, Apoptosis-stimulating of p53 protein 2:
1
1128
Ank
SH..
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: P04637 | TP53BP2 | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

P04637.H179Q

Completed successfully

Protein, domain: P04637 P53+P53_tetramer

Interacting with: TP53BP2 Ank

PDB templates used: 1ycs_A, 1ycs_B

Seq identity: 1.000, 1.000 Model score: -0.316

ELASPIC ΔΔG: -0.083

ELASPIC2 (EL2) score: -0.484

Mutation in databases: UniProt, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.