ELASPIC home << Job #oncokb << P00533.G719D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

P00533.G719D

Detailed results for job #oncokb produced by ELASPIC
P00533, Epidermal growth factor receptor:
G719D
1
1210
Recep_L_d..
Recep_..
Furin..
Pkinase_Tyr
PLCH1 isoform 3, Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1:
1
1002
EF-hand_like+PI-PLC-X+PI-PLC-Y
EF-h..
C2
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P00533.G719D

Completed successfully

Protein, domain: P00533 Pkinase_Tyr

Interacting with: PLCH1 isoform 3 EF-hand_7

PDB templates used: 2x0g_A, 2x0g_B

Seq identity: 0.282, 0.328 Model score: 1.158

ELASPIC ΔΔG: 0.774

ELASPIC2 (EL2) score: 1.833

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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