ELASPIC home << Job #oncokb << P00519.E355A
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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P00519.E355A

Detailed results for job #oncokb produced by ELASPIC
P00519, Tyrosine-protein kinase ABL1:
E355A
1
1130
F_act..
SH..
SH2
Pkinase_Tyr
EPHA8, Ephrin type-A receptor 8:
1
1005
fn3
SAM_1
fn3
EphA2_TM+Pkinase_Tyr
Ephrin_lbd
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Protein: P00519 | EPHA8 | Cofactors | All
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P00519.E355A

Completed successfully

Protein, domain: P00519 Pkinase_Tyr

Interacting with: EPHA8 EphA2_TM+Pkinase_Tyr

PDB templates used: 1opj_B, 1opj_A

Seq identity: 0.996, 0.390 Model score: -0.091

ELASPIC ΔΔG: 0.758

ELASPIC2 (EL2) score: 1.370

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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