ELASPIC home << Job #oncokb << O75874.Y139D
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O75874.Y139D

Detailed results for job #oncokb produced by ELASPIC
O75874, Isocitrate dehydrogenase [NADP] cytoplasmic:
Y139D
1
414
Iso_dh
IDH1, Isocitrate dehydrogenase [NADP] cytoplasmic:
1
414
Iso_dh
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Model: Wild-type | Mutant | Both
Protein: O75874 | IDH1 | Cofactors | All
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O75874.Y139D

Completed successfully

Protein, domain: O75874 Iso_dh

Interacting with: IDH1 Iso_dh

PDB templates used: 4l03_B, 4l03_A

Seq identity: 0.998, 0.998 Model score: -1.186

ELASPIC ΔΔG: -0.043

ELASPIC2 (EL2) score: 2.661

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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