ELASPIC home << Job #oncokb << O60674.S1025C
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.S1025C

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
S1025C
1
1132
Pkinase_Tyr
Pkinase_Tyr
GRB10 isoform 3, Isoform 2 of Growth factor receptor-bound protein 10:
1
536
BPS
RA+PH
SH2
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O60674.S1025C

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: GRB10 isoform 3 BPS

PDB templates used: 2auh_A, 2auh_B

Seq identity: 0.314, 0.784 Model score: -0.205

ELASPIC ΔΔG: 0.678

ELASPIC2 (EL2) score: -0.953

Mutation run by user.

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Citation

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