ELASPIC home << Job #oncokb << O60674.K539L
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O60674.K539L

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
K539L
1
1132
Pkinase_Tyr
Pkinase_Tyr
MAP3K5, Mitogen-activated protein kinase kinase kinase 5:
1
1374
Pkinase
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Model: Wild-type | Mutant | Both
Protein: O60674 | MAP3K5 | Cofactors | All
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O60674.K539L

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: MAP3K5 Pkinase

PDB templates used: 4l00_B, 4l00_A

Seq identity: 0.524, 0.247 Model score: 0.098

ELASPIC ΔΔG: 1.369

ELASPIC2 (EL2) score: -2.010

Mutation in databases: ClinVar, UniProt, COSMIC, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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