ELASPIC home << Job #oncokb << O60674.I1018F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.I1018F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
I1018F
1
1132
Pkinase_Tyr
Pkinase_Tyr
NFKB1, Nuclear factor NF-kappa-B p105 subunit:
1
968
RHD
Ank
Death
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Protein: O60674 | NFKB1 | Cofactors | All
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O60674.I1018F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: NFKB1 Ank

PDB templates used: 3zu7_A, 3zu7_B

Seq identity: 0.279, 0.317 Model score: 1.753

ELASPIC ΔΔG: 1.159

ELASPIC2 (EL2) score: 0.391

Mutation run by user.

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Citation

If you use these results, please cite the papers on this page.