ELASPIC home << Job #oncokb << O60674.I1018F
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.I1018F

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
I1018F
1
1132
Pkinase_Tyr
Pkinase_Tyr
FAK1 isoform 2, Isoform 2 of Focal adhesion kinase 1:
1
879
Pkinase_Tyr+Pkinase_Tyr
Focal_AT
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O60674.I1018F

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: FAK1 isoform 2 Pkinase_Tyr+Pkinase_Tyr

PDB templates used: 4e5w_A, 4e5w_B

Seq identity: 0.559, 0.340 Model score: 0.040

ELASPIC ΔΔG: 0.723

ELASPIC2 (EL2) score: 0.635

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

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