ELASPIC home << Job #oncokb << O60674.F1061W
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
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O60674.F1061W

Detailed results for job #oncokb produced by ELASPIC
O60674, Tyrosine-protein kinase JAK2:
F1061W
1
1132
Pkinase_Tyr
Pkinase_Tyr
FYN isoform 3, Isoform 3 of Tyrosine-protein kinase Fyn:
1
482
Pkinase_Tyr
SH3_1
SH2
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O60674.F1061W

Completed successfully

Protein, domain: O60674 Pkinase_Tyr

Interacting with: FYN isoform 3 Pkinase_Tyr

PDB templates used: 3dqw_B, 3dqw_D

Seq identity: 0.308, 0.844 Model score: -0.424

ELASPIC ΔΔG: 0.757

ELASPIC2 (EL2) score: -0.095

Mutation run by user.

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Citation

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