ELASPIC home << Job #oncokb << O00459.K376N
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O00459.K376N

Detailed results for job #oncokb produced by ELASPIC
O00459, Phosphatidylinositol 3-kinase regulatory subunit beta:
K376N
1
728
RhoGAP
SH2
SH2
FGR, Tyrosine-protein kinase Fgr:
1
529
SH3_1
SH2
Pkinase_Tyr
Select affected interaction:

Switch to the slower HTML5 mode if the applet isn't showing.
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Protein: O00459 | FGR | Cofactors | All
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

O00459.K376N

Completed successfully

Protein, domain: O00459 SH2

Interacting with: FGR SH2

PDB templates used: 2dx0_A, 2dx0_B

Seq identity: 0.370, 0.420 Model score: 0.593

ELASPIC ΔΔG: 0.699

ELASPIC2 (EL2) score: 1.735

Mutation run by user.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.