ELASPIC home << Job #oncokb << O00329.E1021K
x
Choose which mutations you want to be shown in the result table below.
Reset to show everything.
x
Status of calculations
: Completed with success
: Mutation not in domain
: Running
: In task queue
: Error
When calculations are done, you can click on each mutation to see their detailed results.
x
Try again
can be rerun by clicking the button:
RERUN
For more information about the error, contact us.
x
ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
x
ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O00329.E1021K

Detailed results for job #oncokb produced by ELASPIC
O00329, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform:
E1021K
1
1044
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
PI3_PI4_kinase
VAV2 isoform 3, Isoform 3 of Guanine nucleotide exchange factor VAV2:
1
839
CAMSAP_CH
SH2
SH3_2
PH
C1_1
RhoGEF
SH3_2
Select affected interaction:
Set mode: JAVA | HTML5
Set quality: Best | Normal | Worst
Model: Wild-type | Mutant | Both
Center camera: Protein | Mutation
Clone in larger window
Cartoon: On | Off | Translucent
Sticks: On | Off | Within Å:
Labels: On | Off | Only sticks

O00329.E1021K

Completed successfully

Protein, domain: O00329 PI3_PI4_kinase

Interacting with: VAV2 isoform 3 SH2

PDB templates used: 2y3a_A, 2y3a_B

Seq identity: 0.807, 0.296 Model score: -0.191

ELASPIC ΔΔG: 0.572

ELASPIC2 (EL2) score: -0.532

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

If you use these results, please cite the papers on this page.