ELASPIC home << Job #oncokb << O00329.E1021K
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ELASPIC ΔΔG
The final Gibbs free energy change (ΔΔG) in kcal/mol is predicted using more than 70 sequential, molecular and energetic features with the Stochastic Gradient Boosting of Decision Trees algorithm.
For more information see the ELASPIC publication.
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ELASPIC2 (EL2) score
The ELASPIC2 (EL2) score is obtained using features generated by pretrained ProteinSolver and ProtBert neural networks with the Stochastic Gradient Boosting of Decision Trees algorithm and a ranking objective function.
For more information see the ELASPIC2 (EL2) publication.

O00329.E1021K

Detailed results for job #oncokb produced by ELASPIC
O00329, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform:
E1021K
1
1044
PI3K_p85B+PI3K_rbd
PI3K_C2+PI3Ka
PI3_PI4_kinase
ZAP70 isoform 3, Isoform 3 of Tyrosine-protein kinase ZAP-70:
1
493
Pkinase_Tyr
SH2
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O00329.E1021K

Completed successfully

Protein, domain: O00329 PI3_PI4_kinase

Interacting with: ZAP70 isoform 3 SH2

PDB templates used: 2y3a_A, 2y3a_B

Seq identity: 0.807, 0.323 Model score: -0.330

ELASPIC ΔΔG: 1.370

ELASPIC2 (EL2) score: -0.346

Mutation in databases: UniProt, COSMIC.

Download:  PDBwt   | PDBmut

Citation

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